Renal dysfunction as a predictor of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: validation of the R(2)CHADS(2) index in the ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) and ATRIA (AnTicoagulation and Risk factors In Atrial fibrillation) study cohorts
| Field | Value |
|---|---|
| Model ID | 13-016-01 |
| Model Name | Renal dysfunction, CHF, Hypertension, Age, DM, History of Stroke or TIA (R2CHADS2) Score |
| Pubmed ID | 23212720 |
| First Author | Piccini |
| Journal | Circulation |
| Year | 2013 |
| Title | Renal dysfunction as a predictor of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: validation of the R(2)CHADS(2) index in the ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) and ATRIA (AnTicoagulation and Risk factors In Atrial fibrillation) study cohorts |
| Primary Index Condition | Arrhythmia |
| Secondary Index Condition | Atrial Fibrillation |
| Outcome | Stroke |
| Model Sample Size | 14264 |
| Cohort Sample Size | 14264 |
| Number of Events | 575 |
| Follow-Up Duration | Long (>6 months) |
| AUROC | 0.587 |
| Calibration Reported | 1 |
| Covariates | Prior stroke or TIA; Cockcroft/Gault CrCl, <=40 mL/min; Cockcroft/Gault CrCl, 41-50 mL/min; Cockcroft/Gault CrCl, 51-60 mL/min; Cockcroft/Gault CrCl, 61-70 mL/min; Cockcroft/Gault CrCl, 71-80 mL/min; Cockcroft/Gault CrCl, 81-90 mL/min; Cockcroft/Gault CrCl, 91-100 mL/min; Cockcroft/Gault CrCl, 101-110 mL/min; Cockcroft/Gault CrCl, 111-120 mL/min; Cockcroft/Gault CrCl, >120 mL/min; Diastolic blood pressure, <=70 mm Hg; Diastolic blood pressure, 71-80 mm Hg; Diastolic blood pressure, 81-90 mm Hg; Diastolic blood pressure, 91-100 mm Hg; Diastolic blood pressure, >100 mm Hg; History of vascular disease (CAD, MI, PAD); New or persistent atrial fibrillation; Heart rate, <=70 bpm; Heart rate, 71-80 bpm; Heart rate, 81-90 bpm; Heart rate, 91-100 bpm; Heart rate, >100 bpm; Female sex; Diabetes; Hypertension; Age, <=65 y; Age, 66-75 y; Age, >75 y; No heart failure |
| Mesh Terms | To be updated |
| Number of Validations | 7 |
External Validations
| Yes | |
| 7 | |
| 0.672 |
| 1st Author | Year | Sample Size | AUC | Calibration | Relatedness |
|---|---|---|---|---|---|
| Bautista | 2015 | 98 | 0.631 | No | Related |
| Peguero | 2016 | 2263 | 0.64 | No | Mismatch |
| Abumuaileq | 2015 | 154 | 0.65 | No | Related |
| Piccini | 2013 | 13559 | 0.672 | No | Related |
| Abumuaileq | 2015 | 911 | 0.70 | No | Distantly Related |
| Bautista | 2015 | 524 | 0.718 | No | Related |
| Bautista | 2015 | 426 | 0.724 | No | Related |