Predictors of mortality and morbidity in patients with chronic heart failure

Field Value
Model ID06-002-01
Model NameCandesartan in Heart Failure: Assessment of Reduction in Mortality and morbidity (CHARM) - CV Death or HF Hospitalization
Pubmed ID16219658
First AuthorPocock
JournalEuropean Heart Journal
TitlePredictors of mortality and morbidity in patients with chronic heart failure
Primary Index ConditionChronic Heart Failure (CHF)
Secondary Index ConditionN/A
Model Sample Size7599
Cohort Sample Size7599
Number of Events2460
Follow-Up DurationLong (>6 months)
Calibration Reported1
CovariatesAge (per 10 years over age 60); Diabetes: insulin-treated; Diabetes: other; Ejection fraction (per 5% decrease below 45); Prior HF hospitalization within 6 months; Prior HF hospitalization but not within 6 months; Cardiomegaly; Diagnosis of CHF over 2 years ago; NYHA class III; NYHA class IV; DBP (per 10 mmHg decrease); Bundle branch block; Heart rate (per 10 bpm); Candesartan (vs. placebo); Dependent edema; Pulmonary crackles; Rest dyspnea; Female; Atrial fibrillation; BMI (per 1 kg/m^2 decrease below 27.5); Mitral regurgitation; Previous myocardial infarction; Pulmonary edema; Current smoker
Mesh TermsTo be updated
Number of Validations1

External Validations

1st Author Year Sample Size AUC Calibration Relatedness
Pfister 2008 290 0.79 No Distantly Related